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We are migrating FusionHub to new web address https://fusionhub.demopersistent.com , https://fusionhub.persistent.co.in will not be available from Feb 2022

FusionHub

Gene fusion is a chromosomal rearrangement event which plays a significant role in cancer due to the oncogenic potential of the chimeric protein generated through fusions. Owing to the availability of large number of public domain databases providing gene fusion information and lack of any search engine to collectively obtain information from these databases, we have developed FusionHub, a unified platform that simplifies large scale annotation of fusion genes. Additionally, to make FusionHub a centralized hub for all kind of gene fusion analysis, along with annotation module, two other features which are visualization and siRNA designing were also integrated.

Citation

Please cite if you find FusionHub useful.
FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer
Panigrahi P, Jere A, Anamika K (2018) FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer. PLoS ONE 13(5): e0196588. https://doi.org/10.1371/journal.pone.0196588

Four modules of FusionHub

Please note due to some technical challenges few modules are not functional right now. We are working on it and update.

• FusionSearch: Allows to annotate any number of input fusion genes.
• FusionView: Allows to visualize fusion events via Circos/Domain/Network view.
• siRNA design: Allows to design siRNA for input fusion sequence
• Oncofuse: Allows to predict oncogenic potential of fusion genes

FusionSearch Features

• Batch submission
• Three modes of searching
  • Gene pair-wise
  • Gene-wise
  • Chromosome-wise
• Integration of 28 datasets

  Cosmic	ChimerKB	ChimerPUB	ChimerSEQ	ChiTaRS
  Farecafe	TicDB	Tumor Fusion Portal	FusionCancer	ConjoinG
  18Cancers	Oesophagus_Dataset	Gliomas_Dataset	Prostate_Dataset	Pancreases_Dataset
  Klijin_Dataset	Known_Fusions	1000Genome	Bodymap2	HPA
  Non_Tumor_Cells	Babiceanu_Dataset	Banned_Dataset	GTEx_Dataset	Fimereli_Dataset
  Cortex_Dataset	ChromothripsisDB database	Manually Added Lists from Literature

FusionView Features

• Circos View
• Domain Architecture View
• Network View

siRNAdesign Features

• Four siRNA prediction tools
  • BiLTR
  • siDirect
  • eRNAi
  • RNAxs

Updates

• 24 June 2018: New functionality (Gene to BioCyc Pathway mapping) feature is integrated in FusionSearch.
• 24 June 2018: New functionality (Check for non protein-coding gene) feature is integrated in FusionSearch.
• 24 June 2018: New functionality (Gene to Kegg Pathway mapping) is integrated in FusionSearch.
• 22 June 2018: New functionality (Gene to Pfam domain mapping) is integrated in FusionSearch.
• 21 June 2018: Fixed bug related to oncofuse utility. It now shows log message of the tool. Improved the output.
• 18 June 2018: Around 108 fusion genes from this paper is added to Literature dataset of FusionSearch engine.
• 30 May 2018: Fusion genes from ChromothripsisDB is added to FusionSearch engine. Now a total of 28 datasets are searched for fusion genes.
• 28 May 2018: Table Pagination feature integrated on FusionHub. All results table are now paginated.
• 25 May 2018: Oncofuse Utility is added to FusionHub
• 25 May 2018: Fusion genes from Cortex_Dataset is added to FusionSearch engine. Now a total of 27 datasets are searched for fusion genes.
• 9 Apr 2018: Fusiongenes from this article is added to FusionSearch engine. . Now a total of 26 datasets are searched for fusion genes
• 8 Apr 2018: Fimereli_Dataset added to FusionSearch engine. . Now a total of 25 datasets are searched for fusion genes

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